Electron tomographic methods for studying the chemical synapse.

OL. 79 0091 reserved. 241 DOI: 10.1016/S0091 -679X -679X II. N eurons, Neural Networks, and the Synapse III. E T and the Synapse IV. T ypes of Neurons and Synapses A. N euromuscular Junction Synapse B. R ibbon Synapses C. C NS Synapses V. S ources of Neurons for Structural Studies VI. M ethods for Assessing Neuron and Synapse Integrity V II. R apid Freezing and HPF of Neurons V III. M odeling and Analysis of Synaptic Structures A. S ize and Organization of the Vesicle Pool B. O rganization of the Postsynaptic Density Proteins C. S ynaptic Cleft Complexes D. E ndosomal Compartments E. M icrotubule and Neurofilament Arrangements IX. S timulation-Dependent Changes in Synaptic Structure X. T he Future of EM Tomography and Synapses XI. C onclusions R eferences